EU drug regulator OKs Novartis' meningitis B shot

LONDON (AP) — Europe's top drug regulator has recommended approval for the first vaccine against meningitis B, made by Novartis AG.

There are five types of bacterial meningitis. While vaccines exist to protect against the other four, none has previously been licensed for type B meningitis. In Europe, type B is the most common, causing 3,000 to 5,000 cases every year.

Meningitis mainly affects infants and children. It kills about 8 percent of patients and leaves others with lifelong consequences such as brain damage.

In a statement on Friday, Andrin Oswald of Novartis said he is "proud of the major advance" the company has made in developing its vaccine Bexsero. It is aimed at children over two months of age, and Novartis is hoping countries will include the shot among the routine ones for childhood diseases such as measles.

Novartis said the immunization has had side effects such as fever and redness at the injection site.

Recommendations from the European Medicines Agency are usually adopted by the European Commission. Novartis also is seeking to test the vaccine in the U.S.

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Israel says prefers diplomacy but ready to invade Gaza

GAZA/JERUSALEM (Reuters) - Israel bombed dozens of targets in the Gaza Strip on Monday and said that while it was prepared to step up its offensive by sending in troops, it preferred a diplomatic solution that would end Palestinian rocket fire.


Mediator Egypt said a deal for a truce to end the fighting could be close. The leader of Hamas said it was up to Israel to end the new conflict it had started. Israel says its strikes are to halt Palestinian rocket attacks.


U.N. Secretary-General Ban Ki-moon, touring the region in hopes of helping broker a peace arrived in Cairo, where he met Egypt's foreign minister in preparation for talks with the new, Islamist president, Mohamed Mursi, on Tuesday. He also plans to meet Israeli Prime Minister Benjamin Netanyahu in Jerusalem.


Israeli attacks on the sixth day of fighting raised the number of Palestinian dead to 101, the Hamas-run Health Ministry said, listing 24 children among them. Hospital officials in Gaza said more than half of those killed were non-combatants. Three Israeli civilians died on Thursday in a rocket strike.


Militants in the Gaza Strip fired 110 rockets at southern Israel on Monday, causing no casualties, police said.


For the second straight day, Israeli missiles blasted a tower block in the city of Gaza housing international media. Two people were killed there, one of them an Islamic Jihad militant.


Khaled Meshaal, exiled leader of Hamas, said a truce was possible but the Islamist group, in charge of the Gaza Strip since 2007, would not accept Israeli demands and wanted Israel to halt its strikes first and lift its blockade of the enclave.


"Whoever started the war must end it," he told a news conference in Cairo, adding that Netanyahu, who faces an election in January, had asked for a truce, an assertion a senior Israeli official described as untrue.


Meshaal said Netanyahu feared the domestic consequences of a "land war" of the kind Israel launched four years ago: "He can do it, but he knows that it will not be a picnic and that it could be his political death and cost him the elections."


For Israel, Vice Prime Minister Moshe Yaalon has said that "if there is quiet in the south and no rockets and missiles are fired at Israel's citizens, nor terrorist attacks engineered from the Gaza Strip, we will not attack."


Yaalon also said Israel wanted an end to Gaza guerrilla activity in the neighboring Egyptian Sinai peninsula.


Although 84 percent of Israelis supported the current Gaza assault, according to a poll by Israel's Haaretz newspaper, only 30 percent wanted an invasion, while 19 percent wanted their government to work on securing a truce soon.


DIPLOMACY "PREFERRED"


"Israel is prepared and has taken steps, and is ready for a ground incursion which will deal severely with the Hamas military machine," a senior official close to Netanyahu told Reuters.


"We would prefer to see a diplomatic solution that would guarantee the peace for Israel's population in the south. If that is possible, then a ground operation would no longer be required. If diplomacy fails, we may well have no alternative but to send in ground forces," he added.


Egypt, where Mursi has his roots in the Muslim Brotherhood seen as mentors to Hamas, is acting as a mediator in the biggest test yet of Cairo's 1979 peace treaty with Israel since the fall of Hosni Mubarak.


"I think we are close, but the nature of this kind of negotiation, (means) it is very difficult to predict," Egyptian Prime Minister Hisham Kandil, who visited Gaza on Friday in a show of support for its people, said in an interview in Cairo for the Reuters Middle East Investment Summit.


Egypt has been hosting leaders of both Hamas and Islamic Jihad, a smaller armed faction.


Israeli media said a delegation from Israel had also been to Cairo for truce talks. A spokesman for Netanyahu's government declined comment on the matter.


Egypt's foreign minister, who met U.N. chief Ban on Monday, is expected to visit Gaza on Tuesday with a delegation of Arab ministers.


THOUSANDS MOURN FAMILY


Thousands turned out on Gaza's streets to mourn four children and five women, among 11 people killed in an Israeli strike that flattened a three-storey home the previous day.


The bodies were wrapped in Palestinian and Hamas flags. Echoes of explosions mixed with cries of grief and defiant chants of "God is greatest".


The deaths of the 11 in an air strike drew more international calls for an end to six days of hostilities and could test Western support for an offensive Israel billed as self-defense after years of cross-border rocket attacks.


Israel said it was investigating its air strike that brought the home crashing down on the al-Dalu family, where the dead spanned four generations. Some Israeli newspapers said the wrong house may have been mistakenly targeted.


In scenes recalling Israel's 2008-2009 winter invasion of the coastal enclave, tanks, artillery and infantry have massed in field encampments along the sandy, fenced-off border and military convoys moved on roads in the area.


Israel has also authorized the call-up of 75,000 military reservists, so far mobilizing around half that number.


The Gaza fighting adds to worries of world powers watching an already combustible region, where several Arab autocrats have been toppled in popular revolts for the past two years and a civil war in Syria threatens to spread beyond its borders.


In the absence of any prospect of permanent peace between Israel and Islamist factions such as Hamas, mediated deals for each to hold fire unilaterally have been the only formula for stemming bloodshed in the past.


Israel's declared goal is to deplete Gaza arsenals and force Hamas to stop rocket fire that has hit Israeli border towns for years.


Hamas and other groups in Gaza are sworn enemies of the Jewish state which they refuse to recognize and seek to eradicate, claiming all Israeli territory as rightfully theirs.


Hamas won legislative elections in the Palestinian Territories in 2006. A year later, after the collapse of a unity government under President Mahmoud Abbas, the Islamist group seized Gaza in a brief civil war with Abbas's forces.


(Writing by Jeffrey Heller, Dan Williams and Peter Graff; Editing by Alastair Macdonald)

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US, Britain warn of risks of Israeli ground war

BANGKOK (AP) — The U.S. and Britain on Sunday warned about the risks of Israel expanding its air assault on the Gaza Strip into a ground war, while vigorously defending the Jewish state's right to protect against rocket attacks.

The remarks by President Barack Obama and Britain Foreign Secretary William Hague were part of a diplomatic balancing act by the West as it desperately seeks an end to violence without alienating its closest ally in the region.

"Israel has every right to expect that it does not have missiles fired into its territory," President Barack Obama said at a news conference in Bangkok at the start of a three-nation visit to Asia.

"If that can be accomplished without a ramping up of military activity in Gaza, that's preferable," Obama said. "It's not just preferable for the people of Gaza. It's also preferable for Israelis, because if Israeli troops are in Gaza, they're much more at risk of incurring fatalities or being wounded."

The president spoke shortly before an Israeli airstrike leveled a home in a residential neighborhood. Palestinian medical officials said at least 11 civilians, mostly women and children, were killed. The attack was the single deadliest incident of the 5-day-old Israeli operation.

The Israeli military said the target was a top rocket mastermind of the Islamic Jihad militant group. The claim could not be immediately verified, and the attack raised speculation that Israel could face increased international pressure if the civilian death toll continued to rise.

Hague said Hamas, Gaza's militant rulers, "bears principal responsibility" for initiating the violence and must stop all rocket attacks on Israel. But Hague also made clear the diplomatic risks of an Israeli escalation.

"A ground invasion is much more difficult for the international community to sympathize with or support, including the United Kingdom," he said.

Israeli officials say the airstrikes are aimed at ending months of rocket fire out of the Hamas-ruled territory. Israel began the offensive with an unexpected airstrike that killed Hamas' military chief, and since then has targeted suspected rocket launchers and storage sites.

The Mideast ally is now at a crossroads: launch a ground invasion or pursue Egyptian-led truce efforts. But with Israel and Hamas far apart on any terms of cease-fire, Israeli Prime Minister Benjamin Netanyahu declared at the start of the weekly Cabinet meeting: "The Israeli military is prepared to significantly expand the operation."

The crisis threatened to overshadow Obama's trip to Asia, which includes stops in Myanmar and Cambodia as part of a broader effort to expand the U.S. economic and military presence in a region long dominated by China.

So far, the U.S. has thrown its weight behind Israel, and Obama has called on Egypt and Turkey to intervene on Israel's behalf. Obama said the Palestinians won't have a chance to pursue their own state and a lasting peace with Israel so long as rockets are fired into Israel.

"If we're serious about wanting to resolve this situation and create a genuine peace process, it starts with no more missiles being fired into Israel's territory, and that then gives us the space to try to deal with these longstanding conflicts that exist," Obama said.

Obama pointed to the next 48 hours "to see what kind of progress we can make."

He said he has told Egypt's president, Mohammed Morsi, and Turkey's prime minister, Recep Tayyip Erdogan that "those who champion the cause of the Palestinians should recognize that if we see a further escalation of the situation in Gaza, then the likelihood of us getting back on any kind of peace track that leads to a two-state solution is going to be pushed off way into the future."

Members of the U.S. Congress, which overwhelmingly supports Israel, criticized Egypt and Turkey for not doing enough to intervene. They said all eyes were on President Mohammed Morsi, Egypt's first civilian and freely elected leader.

"Egypt, watch what you do and how you do it," said Sen. Sen. Lindsey Graham, R-S.C., in an interview on NBC's "Meet the Press." ''You're teetering with the Congress on having your aid cut off if you keep inciting violence between the Israelis and the Palestinians."

In a separate interview on ABC's "This Week," Sen. Carl Levin, chairman of the Armed Services Committee, called Egypt's response to the crisis "pretty weak" so far.

"I think that they're going to have to take some very serious steps diplomatically to make it clear to Hamas that they're going to lose support in the Arab world if they continue these rocket attacks on Israel," said Levin, D-Mich.

Lawmakers also blamed Iran for arming Hamas militants, and questioned Egypt's role in that.

"My guess is there has to be some tacit involvement in Egypt and the border or these things wouldn't be getting in to Gaza," said Rep. C.A. "Dutch" Ruppersberger of Maryland, the top Democrat on the House Intelligence Committee.

Sen. Joseph Lieberman, I-Conn., said he thinks the threat of a ground war is overblown.

"I don't think the Israelis really want a ground war," he told "Fox News Sunday." ''They'll go into Gaza if they feel they need to, to eliminate the remainder of the missiles. ... So really, the decision is up to Hamas, as to whether there will be a ground invasion of Gaza or not."

____

Flaherty reported from Washington.

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'Twilight' finale dawns with $141.3M weekend

LOS ANGELES (AP) — The sun has set on the "Twilight" franchise with one last blockbuster opening for the supernatural romance.

"The Twilight Saga: Breaking Dawn — Part 2" sucked up $141.3 million domestically over opening weekend and $199.6 million more overseas for a worldwide debut of $340.9 million, according to studio estimates Sunday.

The finale ranks eighth on the list of all-time domestic debuts, and leaves "Twilight" with three of the top-10 openings, joining 2009's "New Moon" (No. 7 with $142.8 million) and last year's "Breaking Dawn — Part 1" (No. 9 with $138.1 million).

Last May's "The Avengers" is No. 1 with $207.4 million. "Batman" is the only other franchise with more than one top-10 opening: July's "The Dark Knight Rises" (No. 3 with $160.9 million) and 2008's "The Dark Knight" (No. 4 with $158.4 million).

Though "Twilight" still is a female-driven franchise, with girls and women making up 79 percent of the opening-weekend audience, the finale drew the series' biggest male crowds. Action-minded guys had more to root for in the finale as Kristen Stewart, Robert Pattinson and Taylor Lautner join in a colossal battle to end the story of warring vampires and werewolves.

"Our male audience particularly has enjoyed this film," said Richie Fay, head of distribution for Lionsgate, whose Summit Entertainment banner releases the "Twilight" movies. "With the action scenes in this one, we're hoping the holdover business will reflect the fact that males have kind of found it out."

The movie also helped lift Lionsgate into the big leagues among Hollywood studios. Paced by its $400 million smash with "The Hunger Games" and now the "Twilight" finale, Lionsgate surpassed $1 billion at the domestic box office for the first time.

Some box-office watchers had expected the last "Twilight" movie to open with a franchise record the way the "Harry Potter" finale did last year with $169.2 million, the second-best domestic debut on the charts.

"I thought that for the final installment, it might eclipse the franchise record, but to look at $141.3 million and say that's a disappointment, that's kind of crazy," said Paul Dergarabedian, an analyst for box-office tracker Hollywood.com. "It's one of the most consistently performing franchises of all time."

The "Twilight" finale took over the No. 1 spot from Sony's James Bond adventure "Skyfall," which slipped to second place with $41.5 million domestically in its second weekend. "Skyfall" raised its domestic total to $161.3 million.

The franchise's third film starring Daniel Craig as Bond, "Skyfall" began rolling out overseas in late October and has hit $507.9 million internationally at the box office. The film's global total climbed to $669.2 million, helping to lift Sony to its best year ever with $4 billion worldwide, topping the studio's $3.6 billion haul in 2009.

"Skyfall" passed the previous franchise high of $599.2 million worldwide for 2006's "Casino Royale."

Steven Spielberg and Daniel Day-Lewis' Civil War drama "Lincoln" expanded nationwide after a week in limited release and came in at No. 3 with $21 million. Distributed by Disney, "Lincoln" lifted its domestic haul to $22.4 million.

The comic drama "Silver Linings Playbook," released by the Weinstein Co., got off to a good start in limited release, taking in $458,430 in 16 theaters for a solid average of $28,652 a cinema. By comparison, the "Twilight" finale averaged $34,717 in 4,070 theaters.

"Silver Linings Playbook" stars Bradley Cooper, Jennifer Lawrence and Robert De Niro in a quirky romance involving a man fresh out of a psychiatric hospital and an emotionally troubled young widow.

Keira Knightley's period drama "Anna Karenina" also started well in limited release with $315,395 in 16 theaters, for an average of $19,712. The Focus Features film stars Knightley in the title role of Leo Tolstoy's tragic romance.

Estimated ticket sales for Friday through Sunday at U.S. and Canadian theaters, according to Hollywood.com. Where available, latest international numbers also are included. Final domestic figures will be released Monday.

1. "The Twilight Saga: Breaking Dawn — Part 2," $141.3 million ($199.6 million international).

2. "Skyfall," $41.5 million ($49.6 million international).

3. "Lincoln," $21 million.

4. "Wreck-It Ralph," $18.3 million ($4.8 million international).

5. "Flight," $8.6 million ($1 million international).

6. "Argo," $4.1 million.

7. "Taken 2," $2.1 million ($2 million international).

8. "Pitch Perfect," $1.3 million ($4.1 million international).

9. "Here Comes the Boom," $1.2 million.

10 (tie). "Cloud Atlas," $900,000.

10 (tie). "Hotel Transylvania," $900,000.

10 (tie). "The Sessions," $900,000.

___

Online:

http://www.hollywood.com

http://www.rentrak.com

___

Universal and Focus are owned by NBC Universal, a unit of Comcast Corp.; Sony, Columbia, Sony Screen Gems and Sony Pictures Classics are units of Sony Corp.; Paramount is owned by Viacom Inc.; Disney, Pixar and Marvel are owned by The Walt Disney Co.; Miramax is owned by Filmyard Holdings LLC; 20th Century Fox and Fox Searchlight are owned by News Corp.; Warner Bros. and New Line are units of Time Warner Inc.; MGM is owned by a group of former creditors including Highland Capital, Anchorage Advisors and Carl Icahn; Lionsgate is owned by Lions Gate Entertainment Corp.; IFC is owned by AMC Networks Inc.; Rogue is owned by Relativity Media LLC.

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EU drug regulator OKs Novartis' meningitis B shot

LONDON (AP) — Europe's top drug regulator has recommended approval for the first vaccine against meningitis B, made by Novartis AG.

There are five types of bacterial meningitis. While vaccines exist to protect against the other four, none has previously been licensed for type B meningitis. In Europe, type B is the most common, causing 3,000 to 5,000 cases every year.

Meningitis mainly affects infants and children. It kills about 8 percent of patients and leaves others with lifelong consequences such as brain damage.

In a statement on Friday, Andrin Oswald of Novartis said he is "proud of the major advance" the company has made in developing its vaccine Bexsero. It is aimed at children over two months of age, and Novartis is hoping countries will include the shot among the routine ones for childhood diseases such as measles.

Novartis said the immunization has had side effects such as fever and redness at the injection site.

Recommendations from the European Medicines Agency are usually adopted by the European Commission. Novartis also is seeking to test the vaccine in the U.S.

Read More..

Medics: Israel strike intended for militants kills 11 Gaza civilians

GAZA CITY, Gaza Strip (AP) — An Israeli missile flattened a two-story house in a residential neighborhood of Gaza City on Sunday, killing at least 11 civilians, mostly women and children, Palestinian medical officials said, as Israel expanded a military offensive to target homes of wanted militants.

The attack, which Israel said targeted a militant, was the single deadliest incident of the five-day-old Israeli operation and hiked a toll Sunday that was already the highest number of civilians killed in one day, according to Gaza medics. The bloodshed is likely to raise international pressure for a cease-fire, with Egypt taking the leading role in mediating between Israel and Hamas.

President Barack Obama said he had been in touch with the leaders of Israel, Egypt, and Turkey in an effort to halt the fighting. "We're going to have to see what kind of progress we can make in the next 24, 36, 48 hours," he said.

Obama cautioned against a potential Israeli ground invasion into Gaza, warning it could only deepen its death toll. At the same time, he blamed Palestinian militants for starting the round of fighting by raining rockets onto Israel, and he defended Israel's right to defend itself.

"Israel has every right to expect that it does not have missiles fired into its territory," Obama said in Thailand at the start of a three-nation tour in Asia.

An Israeli envoy arrived in Cairo on Sunday and held talks with Egyptian officials on a ceasefire, according to Egyptian security officials and Nabil Shaath, a top aide of Palestinian President Mahmoud Abbas who was in the Egyptian capital.

But Israel and Gaza's militant Hamas rulers remain far apart on any terms for a halt in the bloodshed, which has killed 70 Palestinians — including 36 civilians, according to Gaza health officials — and three Israeli civilians.

Hamas is linking a truce deal to a complete lifting of the border blockade on Gaza imposed since Islamists seized the territory by force. Hamas also seeks Israeli guarantees to halt targeted killings of its leaders and military commanders. Israeli officials reject such demands. They say they are not interested in a "timeout," and want firm guarantees that militant rocket fire into Israel will finally end. Past ceasefires have been short lived.

As the offensive moved forward, Israel found itself at a crossroads — on the cusp of launching a ground offensive into Gaza to strike an even tougher blow against Hamas, or pursuing Egyptian-led truce efforts.

"The Israeli military is prepared to significantly expand the operation," Israeli Prime Minister Benjamin Netanyahu declared at the start of the weekly Cabinet meeting.

At the same time, Gaza militants continued their barrage of rocket fire at Israel, firing more than 100, including two at Tel Aviv. More than 10 Israelis were injured by shrapnel, two moderately, according to police spokesman Mickey Rosenfeld. Israel's "Iron Dome" rocket-defense system shot down at least 30 rockets, including the ones aimed at Tel Aviv.

Israel's announcement Sunday that it was widening its campaign to target homes of militants appeared to mark a new and risky phase of the operation, given the likelihood of civilian casualties in the densely populated territory of 1.5 million Palestinians. Israel launched the offensive Wednesday in a bid to end months of intensifying rocket fire from the Hamas-ruled Gaza Strip.

The day's deadliest strike hit the home of the Daloo family in Gaza City, reducing the structure to rubble.

Frantic rescuers pulled the bodies of several children from the ruins of the house, including a toddler and a 5-year-old, as survivors and bystanders screamed in grief. Later, the bodies of the children were laid out in the morgue of Gaza City's Shifa Hospital.

Among the 11 dead were four small children and five women, including an 80-year-old, Gaza health official Ashraf al-Kidra said.

Israeli military spokesman Brig Gen. Yoav Mordechai told Channel 2 TV that the Israeli navy had targeted the building and killed a "global jihad" militant.

"The targets are exact," Mordechai said. "Every (Israeli) missile has an address."

He said the army would continue its operation "as if there were no (cease-fire) talks in Egypt."

The presence of a militant in the house could not be verified. Al-Kidra said the two adult men killed in the strike were civilians.

Sami Abu Zuhri, a Hamas spokesman, said that "the Israeli people will pay the price" for the killing of civilians. One of the rocket attacks targeting Tel Aviv came soon after the strike on the Daloo home.

More than a dozen homes of Hamas commanders or families linked to Hamas were struck on Sunday. Though most were empty — their inhabitants having fled to shelter — at least three still had families in them. Al-Kidra said 19 of the 24 people killed Sunday were civilians, mostly women and children.

Israeli Vice Premier Moshe Yaalon said civilian casualties are inevitable.

"You can't avoid collateral damage if they position the rockets in densely populated areas, in mosques, school yards. We shouldn't be blamed for the outcome," he said.

Israel also struck two high-rise buildings housing media outlets, damaging the top floor offices of the Hamas TV station, Al Aqsa, and a Lebanese-based broadcaster, Al Quds TV, seen as sympathetic to the Islamists. Six Palestinian journalists were wounded, including one who lost a leg, a Gaza press association said.

Foreign broadcasters, including British, German and Italian TV outlets, also had offices in the high-rises.

Two missiles made a direct hit on Al Aqsa TV's 15th floor offices, said Bassem Madhoun, an employee of Dubai TV, which has offices in the same building.

Building windows were blown out and glass shards and debris were scattered on the street below. Some of the journalists who had been inside the building at the time took cover in the entrance hallway.

Lt. Col. Avital Leibovich, an Israeli military spokeswoman, said the strikes targeted Hamas communications equipment on the buildings' rooftops. She accused the group of using journalists as "human shields," and urged journalists to stay clear of Hamas bases and facilities.

The repeated militant rocket fire on Tel Aviv and a volley fired Friday toward Jerusalem have significantly escalated the hostilities by widening the militants' rocket range and putting 3.5 million Israelis, or half the country's population, within reach. The attempt to strike Jerusalem also has symbolic resonance because both Israel and the Palestinians claim the holy city for a capital.

Israeli radio stations repeatedly interrupted their broadcasts to air "Code Red" alerts warning of impending rocket strikes. In the southern city of Ashkelon, rocket fire damaged a residential building, punching a hole in the ceiling and riddling the facade with shrapnel.

With fighting showing no signs of slowing, international attempts to broker a ceasefire continued.

Nabil Shaath, an aide to Palestinian President Mahmoud Abbas who was in Cairo, confirmed that the Israeli envoy had arrived in Egypt for talks, saying there are "serious attempts to reach a ceasefire." There was no immediate Israeli confirmation.

Hamas' prime minister, Ismail Haniyeh, spoke to Egyptian President Mohammed Morsi. He told the Egyptian leader he supports such efforts, provided Hamas receives "guarantees that will prevent any future aggression" by Israel, his office said in a statement.

Morsi over the weekend hosted talks with Hamas' supreme leader, as well as leaders from Hamas allies Turkey and Qatar. He also held contacts with Western leaders.

French Foreign Minister Laurent Fabius visited Israel on Sunday to offer his country's help toward forging an "immediate ceasefire," the French government said.

Meeting with Fabius, Israeli Foreign Minister Avigdor Lieberman thanked him for "France's efforts to prevent casualties" but said "the moment that all the terror organizations announce a ceasefire, we can consider all the ideas that French foreign minister and other friends are raising."

___

Aron Heller contributed reporting from Beersheba.

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Asia trip gives Obama opportunity to build legacy

YOKOTA AIR BASE, Japan (AP) — For President Barack Obama, expanding U.S. influence in Asia is more than just countering China or opening up new markets to American businesses. It's also about building his legacy.

Fresh off re-election, Obama will make a significant investment in that effort during a quick run through Southeast Asia that begins Sunday. In addition to stops in Thailand and Cambodia, the president will make an historic visit to Myanmar, where his administration has led efforts to ease the once pariah nation out of international isolation.

The trip marks Obama's fourth visit to Asia in as many years. With a second term now guaranteed, aides say Obama, who kicks off his schedule in Bangkok, will be a regular visitor to the region over the next four years as well.

"Continuing to fill in our pivot to Asia will be a critical part of the president's second term and ultimately his foreign policy legacy," said Ben Rhodes, Obama's deputy national security adviser.

The president's motivations in Asia are both personal and strategic.

Obama, who was born in Hawaii and lived in Indonesia as a child, has called himself America's first "Pacific president." The region gives him an opportunity to open up new markets for U.S. companies, promote democracy and ease fears of China's rise by boosting U.S. military presence in Asia.

The president, like many of his predecessors, had hoped to cement his foreign policy legacy in the Middle East. He visited two major allies in the region, Egypt and Saudi Arabia, on one of his first overseas trip as president and attempted to revive peace talks between Israel and the Palestinians.

But those talks stalled, and fresh outbursts of violence between Israel and the Palestinians make the prospects of a peace accord appear increasingly slim. The Obama-backed Arab Spring democracy push has had mixed results so far, with Islamists taking power in Egypt and progress in Libya tainted by the deadly attacks on the U.S. Consulate in Benghazi. Obama hasn't been back to the region since 2009.

In Asia, however, Obama will be viewed as something of an elder statesman when he returns less than two weeks after winning re-election. The region is undergoing significant leadership changes, most notably in China, where the Communist Party tapped new leaders last week. Japan's prime minister and South Korea's president are also stepping down soon.

"Most of the leaders he'll meet with will not have a tenure as long as he will as president," said Michael Green, an Asia scholar at the Washington-based Center for Strategic and International Studies. "So he'll go into this in a very strong position."

The centerpiece of Obama's whirlwind Asia tour is his visit to Myanmar. It will be the first time a U.S. president has visited the former pariah state.

Myanmar has become something of a pet project for Obama and his national security aides, who have cheered the country's significant strides toward democracy. Obama lifted some U.S. penalties on Myanmar, appointed a permanent U.S. ambassador and hosted democracy leader Aung San Suu Kyi at the White House this year.

Many of the same strategic motivations behind Obama's larger focus on Asia are at play in Myanmar.

The country long has oriented itself toward China, but the easing of sanctions gives American businesses a chance to gain a foothold there. It's also an opportunity for the Obama administration to show other nations in the region, and elsewhere in the world, that there are benefits to aligning with the U.S.

Still, there's little denying that history has been a draw for Obama's team when it comes to its dealings with Myanmar. That's led to criticism from some human rights groups that say Obama's visit is premature given that the country continues to hold political prisoners and has been unable to stem some ethnic violence.

"This trip risks being an ill-timed presidential pat on the back for a regime that has looked the other way as violence rages, destroying villages and communities just in the last few weeks," said Suzanne Nossel, the U.S.-based director of Amnesty International.

Obama's other stops in the region also underscore the potential pitfalls of going all-in in Asia.

Thailand's 2006 coup, which led to the ouster of the prime minister, strained relations with the U.S. and raised questions in Washington about the stability of its longtime regional ally. Cambodia, where Obama's visit also marks the first by a U.S. president, has a dismal human rights record.

White House officials have emphasized that Obama is only visiting Cambodia because it is hosting the East Asia Summit, an annual meeting the U.S. attends. Aides say the president will voice his human rights concerns during his meeting with Hun Sen, Cambodia's long-serving prime minister.

Still, human rights groups fear Obama's visit will be seen within Cambodia as an affirmation of the prime minister and a sign to opposition groups that the U.S. stands with the oppressive government, not with them.

___

Follow Julie Pace at http://twitter.com/jpaceDC

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Lady Gaga tweets some racy images before concert

BUENOS AIRES, Argentina (AP) — Lady Gaga's tweets were getting a lot of attention ahead of her Buenos Aires concert Friday night.

The Grammy-winning entertainer has more than 30 million followers on Twitter and that's where she shared a link this week to a short video showing her doing a striptease and fooling around in a bathtub with two other women.

She told her followers that it's a "surprise for you, almost ready for you to TASTE."

Then, in between concerts in Brazil and Argentina, she posted a picture Thursday on her Twitter page showing her wallowing in her underwear and impossibly high heels on top of the remains of what appears to be a strawberry shortcake.

"The real CAKE isn't HAVING what you want, it's DOING what you want," she tweeted.

Lady Gaga wore decidedly unglamorous baggy jeans and a blouse outside her Buenos Aires hotel Thursday as three burly bodyguards kept her fans at bay. Another pre-concert media event where she was supposed to be given "guest of honor" status by the city government Friday afternoon was cancelled.

After Argentina, she is scheduled to perform in Santiago, Chile; Lima, Peru; and Asuncion, Paraguay, before taking her "Born This Way Ball" tour to Africa, Europe and North America.

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EU drug regulator OKs Novartis' meningitis B shot

LONDON (AP) — Europe's top drug regulator has recommended approval for the first vaccine against meningitis B, made by Novartis AG.

There are five types of bacterial meningitis. While vaccines exist to protect against the other four, none has previously been licensed for type B meningitis. In Europe, type B is the most common, causing 3,000 to 5,000 cases every year.

Meningitis mainly affects infants and children. It kills about 8 percent of patients and leaves others with lifelong consequences such as brain damage.

In a statement on Friday, Andrin Oswald of Novartis said he is "proud of the major advance" the company has made in developing its vaccine Bexsero. It is aimed at children over two months of age, and Novartis is hoping countries will include the shot among the routine ones for childhood diseases such as measles.

Novartis said the immunization has had side effects such as fever and redness at the injection site.

Recommendations from the European Medicines Agency are usually adopted by the European Commission. Novartis also is seeking to test the vaccine in the U.S.

Read More..